Copper binding metallothionein


batch conditions, as well as to examine the uptake of copper (II), lead (II), cadmium (II), and nickel (II) by silica immobilized cells of this strain of cyanobacteria under flow conditions. Experiments were conducted to find optimal binding pH, time required for binding, and maximal capacity for binding of each metal. The Native Copper- and Zinc- Binding Protein Metallothionein Blocks Copper-Mediated Aβ Aggregation and Toxicity in Rat Cortical Neurons PLOS ONE , Aug 2010 Roger S. Chung , Claire Howells , Emma D. Eaton , Lana Shabala , Kairit Zovo , Peep Palumaa , Rannar Sillard , Adele Woodhouse , William R. Bennett , Shannon Ray , et al. Copper homeostasis in yeast involves a copper binding protein, metallothionein, and a trans-acting regulatory protein that activates transcription of the metallothionein gene in response to copper ions. We show that the regulatory protein specifically binds to the metallothionein gene control sequences in the presence, but not in the absence, of copper. Both the DNA binding and ... Jan 15, 2002 · Copper is both essential for life and toxic. Aberrant regulation of copper at the level of intracellular transport has been associated with inherited diseases, including Wilson’s disease (WND) in humans. WND results in accumulation of copper and the copper and zinc-binding protein metallothionein (MT) in liver and other tissues, liver degeneration, and neurological dysfunction. The toxic ...